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Orthopedic Conditions

Joint problems are common in dogs; fortunately, research on stem cell therapy suggests an enduring and efficient solution for regeneration. Cartilage does not heal itself as most other tissues because chondrocytes rarely replicate or repair. Hence the objective of regenerative treatment is to promote cartilage healing, decrease inflammation, pain and secure return of the functionality of the damaged cartilage. Timely intervention, guided by the veterinarian's advice, is essential for effectively addressing the condition which includes:

Orthopedic Conditions Treatment
  • Osteoarthritis: Knee (Patella), Hip, Elbow, Shoulder, Spine
  • Dysplasia: Hip, Shoulder, Patella (Knee Cap), Spinal, Carpal Joint (Waist) - Front Leg.
  • Cranial Cruciate Ligament (CCL): Usually Knee Joint
  • Usually Knee Joint

Target Goals:

  • Reduce inflammation to minimize further damage and discomfort.
  • Protect, support, and repair cartilage.
  • Improve dog's mobility and flexibility for more comfortable movement.
  • Promote tissue regeneration and recovery at injury sites.
  • Prevent or delay degenerative processes associated with the condition.
  • Enhance the repair of the damaged CCL and surrounding tissues.
  • Help regulate long term joint health.

Note:The target goals may vary depending on the severity of the condition and the individual dog's response to treatment. While the treatment aims to have gratifying results to improve the quality of life, it's essential to establish realistic expectations in consultation with the vet familiar with stem cells.

Skin Conditions

Mesenchymal stem cell (MSC) - Bioactive Components has been studied for its potential to promote wound healing in canines. It may be beneficial for various types of wounds, particularly in cases where traditional treatments have been less effective. The conditions include:

  • Atopic Dermatitis & Wounds: Help manage the inflammation and skin damage associated with this common allergic skin condition in dogs.
  • Chronic wounds: Assist in the healing of chronic wounds, such as non-healing ulcers or pressure sores.
Skin Conditions Treatment
  • Burn injuries: Aid in the recovery of canines with burn injuries, helping to reduce inflammation and improve tissue regeneration.
  • Surgical wounds: After surgeries, it can be applied to reduce postoperative complications and promote faster recovery.
  • Wounds with infection: In some cases, help combat infection in wounds by modulating the immune response and promoting tissue repair.
  • Autoimmune Skin Disorders: Certain autoimmune skin conditions in canine, such as lupus, might benefit from stem cell therapy to modulate the immune response.
  • Hair Loss (Alopecia): Promote hair re-growth in cases of alopecia in dogs.

Target Goals:

  • Promote Healing: Enhance the regeneration of damaged skin and accelerate the closure of wounds.
  • Tissue Regeneration: Contribute to tissue repair and regeneration, aiding in the healing of damaged skin and reducing the severity of lesions or wounds.
  • Reduce Inflammation: Contain anti-inflammatory factors that could help to mitigate the inflammatory response, contributing to the healing process.
  • Minimize Itching and Discomfort: Alleviate symptoms such as itching and discomfort thereby improving the overall well-being of the animal.
  • Prevent Recurrence: Address underlying factors contributing to the cause and thereby aiming to reduce the likelihood of wound recurrence.
  • Improve Skin Quality: Improve the overall health and quality of the skin addressing not only the immediate symptoms but also contributing to the long-term management in affected areas.
  • Enhance Skin Barrier Function: A healthier skin barrier can contribute to reduced water loss and improved protection against irritants.

Note: Regular veterinary consultation for monitoring and adjustments to the treatment plan may be necessary for optimizing outcomes based on the individual canine response.

Immunomodulation (Immune Therapy)

As the goal is to boost immunity for better quality of life and delay age-related problems in dogs using Mesenchymal Stem Cell (MSC) – Bioactive Component therapy, the treatment plan would typically focus on supporting the immune system and promoting overall health. It is crucial to follow the veterinarian's specific instructions and treatment plan determined by the individual needs of the canine patient.

Immune Therapy Treatment
Overall Expected Outcome

The veterinarian will take into account factors such as the dog's age, health status, and any pre-existing conditions when determining the most suitable approach to boost immunity and address age-related concerns using MSC – Bioactive Component. These include:

  • Immune System Support: The therapy aims to enhance the immune system's function, providing better protection against infections and age-related decline.
  • Age-Related Health Considerations: Address age-related issues, such as promoting joint health, supporting cognitive function, and minimizing inflammation associated with aging.
  • Overall Wellness Focus: The treatment plan may have a holistic approach, focusing not only on immune system support but also on promoting overall wellness. This could involve addressing age-related issues related to organs, tissues, and other physiological functions.
  • Long-Term Maintenance: Given that the goal is to delay age-related problems, the therapy may be considered as part of a long-term maintenance plan. Depending on the goals, these infusions might be administered periodically to maintain immune system support over time.

Target Goals:

Primary

  • Enhanced Immune Function: Strengthen the canine's immune system to provide better protection against infections and illnesses.
  • Reduced Inflammation: Address age-related inflammation, which is often, associated with various health issues. The aim being to promote overall anti-inflammatory effects.
  • Improved Joint Health: Age-related joint problems are a concern, the target would be to support joint health, reduce discomfort, and enhance mobility.
  • Cognitive Support: Maintain or improve cognitive function, especially if age-related cognitive decline or neurodegenerative conditions are potential concerns.
  • Increased Energy and Vitality: Aim to boost overall energy levels and vitality, contributing to a more active and healthier lifestyle for the canine.
  • Prevention of Age-Related Diseases: Work towards preventing or delaying the onset of common age-related diseases that can impact various organs.
  • Longevity and Quality of Life: Strive to extend the canine's lifespan while ensuring a high quality of life in terms of physical health, mental well-being, and overall comfort.
  • Longevity and Quality of Life: Strive to extend the canine's lifespan while ensuring a high quality of life in terms of physical health, mental well-being, and overall comfort.

Secondary

  • Intravenous (IV) administration of the cytokines and growth factors could positively benefit lung function and potentially influencing factors like blood flow, oxygenation, and nutrient delivery to various organs.

Note: It is crucial to adhere to the veterinarian's instructions familiar with stem cell therapy.tailored to the individual needs of the canine patient.

Optic Condition

The regenerative properties of Mesenchymal Stem Cells (MSCs) aim to promote tissue repair and reduce inflammation, potentially aiding in the recovery of damaged optic nerves. These injuries might result from trauma, inflammation, or other underlying causes. The optic conditions in canines would include:

  • Progressive Retinal Atrophy (PRA)
  • Sudden Acquired Retinal Degeneration Syndrome (SARDS)
  • Optic Nerve Hypoplasia
  • Optic nerve damage
  • Cone Degeneration
Optic Condition Treatment

Target Goals:

The target goals of using allogeneic adipose tissue-derived MSCs for optic nerve injuries in canines would typically include:

  • Promote tissue repair.
  • Reducing inflammation.
  • Restoring or preserving visual function.
  • Improve tissue viability.
  • Modulate immune response.

The treatment should be based on each case in collaboration with veterinary professionals familiar with regenerative treatment.

Nerve Conditions

Mesenchymal stem cell (MSC) therapy is being considered for its potential in treating certain nerve-related conditions in dogs by achieving Anti-Inflammatory Effects; Sensory; Function; Motor Function Improvement; Pain Management and a Better Quality of Life.

Conditions that involve nerve damage or dysfunction that would benefit from MSC treatment include:

Nerve Conditions Treatment
Peripheral Neuropathy

Damage or dysfunction of peripheral nerves that can lead to weakness, numbness, and pain.

Target Goals:

  • Enhance the dog's ability to walk, run, and maintain balance.
  • Alleviate discomfort associated with peripheral neuropathy.
  • Promote regeneration of damaged peripheral nerves.
Intervertebral Disc Disease (IVDD)

A condition affecting the spinal discs that can result in compression of spinal nerves.

Target Goals:

  • Reduce pain and inflammation associated with disc compression.
  • Improve limb function and coordination.
  • Support tissue repair and regeneration of the affected inter-vertebral disc.
Degenerative Myelopathy

A progressive disease affecting the spinal cord that leads to weakness and loss of coordination.

Target Goals:

  • Slow the progression of the disease.
  • Maintain or improve hind limb coordination and strength.
  • Enhance overall quality of life by managing symptoms.
Brachial Plexus Injury

Damage to the network of nerves controlling the front limb.

Target Goals:

  • Promote regeneration of damaged nerves in the brachial plexus.
  • Improve limb function and strength.
  • Alleviate pain associated with the injury.
Peripheral Nerve Injuries

Trauma or injuries to specific peripheral nerves.

Target Goals:

  • Aid in the repair of injured peripheral nerves.
  • Improve motor and sensory function in the affected area.
  • Minimize scar tissue formation at the injury site.

Note: It's important to note that the feasibility and success of MSC treatment can vary among individual dogs and specific conditions. Always consult with a veterinarian with knowledge in regenerative treatment for personalized guidance.

Chronic Organ Conditions Heart, Liver, Kidney

The use of Mesenchymal Stem Cells (MSCs), are being considered for their potential to promote tissue repair and regeneration in the heart, liver, and kidneys. The decision to use MSC therapy is often based on individual patient factors and the severity of the condition limited with conventional treatment options. The therapeutic applications of stem cells in dogs for chronic organ conditions include:

Chronic Treatment

Heart Conditions:

  • Myocardial infarction (heart attack)
  • Cardiomyopathy (disease of the heart muscle)
  • Chronic valvular disease
  • Ischemic Heart Disease (Reduced blood supply to the heart muscle)
  • Pericardial Disease ( Inflammation or other disorders affecting the pericardium - the sac around the heart)

Target Goals:

  • Contribute to cardiac repair by differentiating into cardiac cells and promoting the formation of new blood vessels.
  • Release signaling molecules that stimulate the regeneration of damaged heart tissue and modulate the immune response.
  • Increase in cardiac output, improvement in ejection fraction, and enhanced overall heart function.
  • Alleviation of symptoms such as exercise intolerance, coughing, and difficulty breathing.
  • Promotion of tissue repair and regeneration in the damaged areas of the heart.
  • Increase the dog's ability to engage in physical activity without experiencing fatigue or distress.
  • Improve overall quality of life by reducing clinical signs of heart disease, such as coughing and labored breathing.
  • Enhance the dog's prognosis and contribute to a longer and healthier life.

Liver Conditions:

  • Chronic liver disease
  • Hepatitis
  • Liver fibrosis
  • Cirrhosis
  • Portosystemic Shunts (Abnormal blood vessels diverting blood around the liver)
  • Hepatic Lipidosis (Excessive fat accumulation in the liver)
  • Toxic Liver Injury:(Damage caused by ingestion of certain toxins)

Target Goals:

  • Differentiate into hepatocyte-like cells, supporting liver function.
  • Anti-inflammatory and immunomodulatory effects, helping to reduce liver inflammation and promote tissue repair.
  • Enhance liver function by supporting hepatocyte regeneration and reducing inflammation.
  • Minimize liver fibrosis and scarring.
  • Alleviate symptoms such as jaundice, lethargy, and gastrointestinal disturbances.
  • Improve the liver's ability to detoxify the blood and eliminate waste products.
  • Support the liver's synthetic functions, including the production of proteins necessary for blood clotting and other essential processes.
  • Reduce elevated liver enzymes to within normal ranges.
  • Minimize the risk of complications such as hepatic encephalopathy (brain dysfunction due to liver disease).

Kidney Conditions:

  • Chronic kidney disease
  • Acute kidney injury
  • Glomerulonephritis
  • Renal fibrosis
  • Renal Dysplasia (Abnormal development of the kidneys)
  • Nephrotic Syndrome: (A group of symptoms indicating kidney damage, often associated with proteinuria)
  • Glomerulopathy: (Disorders affecting the glomeruli, the filtering units of the kidneys).

Target Goals:

  • Differentiate into renal cells, aiding in the regeneration of damaged kidney tissue.
  • Exert anti-inflammatory effects and modulate the immune response, potentially reducing kidney inflammation and fibrosis.
  • Enhance kidney function by promoting the regeneration of renal cells.
  • Reduce inflammation in the kidneys.
  • Slow the progression of chronic kidney disease and prevent further damage.
  • Slow the progression of chronic kidney disease and maintain stable renal function.
  • Improve the regulation of electrolytes, such as potassium and phosphorus, in the blood.
  • Help regulate blood pressure, which is often affected in kidney disease.
  • Minimize excessive protein loss in the urine, a common complication of kidney disease.

Note: It is important to note that while scientific studies indicate that MSC therapy holds promise, it may not always result in a complete cure. The goals often include improving quality of life, slowing disease progression, and reducing symptoms. Additionally, the effectiveness of MSC therapy can vary, and outcomes depend on factors such as the specific condition, the stage of the disease, and the overall health of the individual dog.

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